Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study

The purpose of this study is to assess the effects an alternative approach type 2 diabetes prevention. Ninety-six patients with prediabetes (age 52 (10) years; 80% female; BMI 39.2 (7.1) kg/m2) received a continuous remote care intervention focused on reducing hyperglycemia through carbohydrate restricted nutrition therapy for two years in single arm, prospective, longitudinal pilot study. Two-year retention was 75% (72 96 participants). Fifty-one percent participants (49 96) met restriction goals as assessed by blood beta-hydroxybutyrate concentrations more than one-third reported measurements. Estimated cumulative incidence normoglycemia (HbA1c < 5.7% without medication) and ? 6.5% or <6.5% medication other metformin) at were 52.3% 3%, respectively. Prevalence metabolic syndrome, class II greater obesity, suspected hepatic steatosis significantly decreased years. These results demonstrate potential utility alternate prevention, delivered model, normalization glycemia improvement related comorbidities.